MFF || HE MATTERS || Season 10 || Episode 3 || Idiopathic Male Infertility: The Unseen Enemy

IVF

Nearly 30–40% of infertile men are labeled “idiopathic” despite normal evaluation. But unexplained does not mean untreatable. This episode uncovers the hidden biological factors behind idiopathic male infertility—oxidative stress, sperm DNA fragmentation, chromatin damage, inflammation, and metabolic dysfunction. It outlines a structured, time-bound approach to empiric medical therapy, appropriate use of antioxidants, and when additional investigations are necessary. Most importantly, it defines clear decision points for transitioning to Assisted Reproductive Technology (ART) to avoid losing valuable time in fertility care.